A racemic mixture of DMNPC could be synthesized from freebase arecoline inside of a grignard reaction with two-naphthylmagnesium bromide. Much more reactions and separation options can be employed to provide enantiomerically pure items.[1] proceeded by nucleophilic substitution with phenol 119 to help make intermediate B via an interrupted Pummerer DMNPC https://finnbrdpa.ttblogs.com/17460810/dmnpc-reddit-an-overview