Inadequate/Substantial Metabolizers, CYP2D6 The formation of the active metabolite, M1, is mediated by CYP2D6, a polymorphic enzyme. Close to seven% in the populace has minimized exercise in the CYP2D6 isoenzyme of cytochrome P450 metabolizing enzyme procedure. These folks are “inadequate metabolizers” of debrisoquine, dextromethorphan and tricyclic antidepressants, amid other medicine. https://dihydrocodeine-30-mg95628.free-blogz.com/83166149/benesdin-fundamentals-explained