Gastrointestinal (GI): NSAIDs that block COX-1 action have correlations with GI complications due to inhibition of the synthesis of gastroprotective agents like PGE2 together with other prostaglandins. This inhibition results in lowered mucin output by gastric epithelial cells, fewer bicarbonate secretion, and less epithelial cell turnover, among other actions. This https://yogix671yxt4.wikissl.com/user